AOD-9604

AOD-9604 (also called hGH fragment 176-191 or Fragment 176-191) is a synthetic peptide corresponding to the C-terminal region of the human growth hormone molecule. It was designed to reproduce a specific portion of the parent hormone that researchers associate with lipid metabolism.

In the research literature it is studied as a growth-hormone-derived fragment rather than as the full hormone.

It is widely known in fitness and weight-loss circles as a "fat-burning" fragment of human growth hormone, purportedly promoting lipolysis without the broader side effects associated with GH.

AOD-9604 is a modified fragment of the human growth hormone molecule that researchers are investigating for its purported ability to stimulate lipolysis (fat breakdown) and inhibit new fat formation. It is popular in weight-management circles precisely because it is reputed to target fat metabolism without the glucose or growth effects associated with full growth hormone.

In the fitness and biohacking community it is anecdotally reported to support fat loss, improved body composition, and metabolic rate, and it is commonly searched under terms like fat burning, weight management, and hGH fragment.

These lipolytic and metabolic properties remain areas of active or preclinical investigation and community interest, not outcomes established in humans.

In preclinical research, AOD-9604 is examined in the context of lipid metabolism and fat-cell activity. Laboratory and animal-model studies measure markers of lipolysis and lipogenesis and related metabolic signaling.

Investigators compare the fragment's activity to that of the parent hormone to isolate the metabolic effects attributed to this C-terminal region. These observations reflect mechanisms measured in controlled research settings and are not human outcomes.

AOD-9604 is provided lyophilized and should be stored sealed at -20°C, kept dark to protect the peptide. Because this hydrophobic fragment can be slow to dissolve at neutral pH, it is often reconstituted with slightly acidic (dilute acetic acid) water, with reconstituted material held at 4°C for near-term work or divided into aliquots at -80°C to avoid repeated freeze-thaw. An HPLC certificate of analysis is supplied with each lot.