CJC-1295 (No DAC)

CJC-1295 (No DAC), also known as Mod GRF (1-29), is a synthetic analog of the first 29 amino acids of growth-hormone-releasing hormone (GHRH). It carries stabilizing substitutions but omits the Drug Affinity Complex (DAC) that characterizes the long-acting form.

Without DAC, it is described in research as short-acting: it does not bind serum albumin, so its research half-life is much shorter than the DAC-bearing variant used in comparative studies.

It is popularly associated in bodybuilding, biohacking, and anti-aging circles with amplifying natural growth-hormone pulses for leaner physique and faster recovery.

A short-acting growth-hormone-releasing hormone (GHRH) analog, CJC-1295 without DAC is popular in performance and biohacking circles for its purported ability to drive sharp, pulsatile GH release that more closely mimics the body's natural rhythm. Enthusiasts anecdotally report using it in pursuit of lean muscle gains, improved workout recovery, and body-recomposition support.

Researchers are investigating GHRH analogs for their downstream effects on IGF-1, fat metabolism, and tissue repair, and the compound is frequently discussed alongside GH secretagogues like ipamorelin for reputed synergy. It is popularly associated with fat loss, better sleep quality, and anti-aging or skin-quality benefits.

Interest in enhanced GH output also extends to collagen turnover, recovery, and overall vitality; however, these are areas of active or preclinical investigation and community interest, not outcomes established in humans.

As a GHRH-receptor analog, CJC-1295 (No DAC) is studied in preclinical models for its role in pulsatile stimulation of the GH axis. Investigators examine receptor engagement and downstream hormonal markers in cell and animal systems, often pairing it with the ghrelin-receptor agonist Ipamorelin to compare complementary secretagogue pathways.

These findings describe mechanisms measured under controlled laboratory conditions and do not represent outcomes in people.

The peptide ships lyophilized and is kept at -20°C in a sealed, light-protected container. For research use it is reconstituted with bacteriostatic or sterile water, then stored at 4°C for short-term work or divided into aliquots held at -80°C. Each lot is accompanied by an HPLC certificate of analysis.